Welcome to PRECOG: prediction of coupling probabilities of GPCRs

Precog lets you predict coupling probabilites of G-protein coupled receptors (GPCRs) and their mutations with major G-proteins using only sequence information.

It is built by training the logistic-regression algorithm on sequence-based features, derived from a set of Class A GPCRs, whose binding affinities were determined using a

Shedding Assay techniqueInoue, A. et al. TGFα shedding assay: An accurate and versatile method for detecting GPCR activation. Nat. Methods (2012)

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You can paste/upload lists of proteins using most protein or accessions (UniProt, Gene symbols). To analyze the impact of mutations, simply append the positional information as variants/mutants (e.g. TSHR/A623I) separated by a forward slash (/). Refer to examples for more information.